Deep Learning for Respiratory Sound Analysis: A Systematic Review and Meta-Analysis (2019–2024)

Authors

  • Shaima’a Mohammed Nasser Al-Jabali Information Technology Department, Faculty of Engineering and Information Technology, AL-Qalam University, Ibb, Yemen. Author
  • Farhan Nashwan Electrical Engineering Department, Faculty of Engineering, IBB University, IBB, Yemen. Author
  • Waleed M. Altalabi Biomedical Engineering Department, Sana'a Community College, Sana'a, Yemen. Author

DOI:

https://doi.org/10.59167/g1qw6p23

Keywords:

Respiratory sounds, Lung disease classification, Deep learning, Systematic review, Meta-analysis, Multitask learning, Explainable AI

Abstract

Background: Respiratory diseases remain a significant global health burden, particularly in resource-limited settings. Objective: To review and quantitatively analyze deep learning-based models for interpreting respiratory sounds. Methodology: A systematic search was conducted in the PubMed, IEEE Xplore, ScienceDirect, and Scopus databases for the period 2019–2024, using PRISMA 2020 criteria. Of the 678 records accessed, 98 studies met the qualitative criteria, while 42 met the quantitative analysis criteria. Results: An exploratory meta-analysis conducted on a subset of studies reporting native accuracy (k = 9) yielded a pooled accuracy of approximately 90.0% (95% CI: 76.0%–97.0%), with substantial heterogeneity (I² = 99.2%). Conclusion: Deep learning techniques demonstrate promising diagnostic capabilities, but they still face challenges related to reliance on limited databases, poor representation of rare diseases, and difficulty in interpreting their outputs. Implications: Future research should focus on diversifying datasets, enhancing the integration of multimodal data, and developing interpretable or federated learning-based models to support their adoption in clinical settings

References

[1] Momtazmanesh, S., Moghaddam, S.S., Ghamari, S.-H., Rad, E.M., Rezaei, N., Shobeiri, P., Aali, A., Abbasi-Kangevari, M., Abbasi-Kangevari, Z., Abdelmasseh, M. (2023) Global burden of chronic respiratory diseases and risk factors, 1990–2019: an update from the Global Burden of Disease Study 2019, EClinicalMedicine 59: 101936.

[2] Kim, Y., Hyon, Y., Lee, S., Woo, S.-D., Ha, T., Chung, C. (2022) The coming era of a new auscultation system for analyzing respiratory sounds, BMC Pulmonary Medicine 22: 119.

[3] Nguyen, T., Pernkopf, F. (2022) Lung sound classification using co-tuning and stochastic normalization, IEEE Transactions on Biomedical Engineering 69: 2872-2882.

[4] Wall, C., Zhang, L., Yu, Y., Kumar, A., Gao, R. (2022) A deep ensemble neural network with attention mechanisms for lung abnormality classification using audio inputs, Sensors 22: 5566.

[5] He, W., Yan, Y., Ren, J., Bai, R., Jiang, X. (2024) Multi-view spectrogram transformer for respiratory sound classification. In Proceedings of the International Conference on Acoustics, Speech and Signal Processing (ICASSP), IEEE, Seoul, South Korea, 14 – 19 April 2024, pp. 8626-8630.

[6] Moon, H.J., Ji, H., Kim, B.S., Kim, B.J., Kim, K. (2025) Machine learning-driven strategies for enhanced pediatric wheezing detection, Frontiers in Pediatrics 13: 1428862.

[7] Albiges, T., Sabeur, Z., Arbab-Zavar, B. (2025) Features and eigenspectral densities analyses for machine learning and classification of severities in chronic obstructive pulmonary diseases, Intelligence-Based Medicine 11: 100217.

[8] Albakaa, Z.H., Alb-Salih, A.T. (2024) An Evolutionary Deep Learning for Respiratory Sounds Analysis: A Survey. In Proceedings of the International Conference on Forthcoming Networks and Sustainability in the AIoT Era, Springer, Istanbul, Türkiye, 27–29 January 2024, pp. 217-235.

[9] Sabry, A.H., Bashi, O.I.D., Ali, N.N., Al Kubaisi, Y.M. (2024) Lung disease recognition methods using audio-based analysis with machine learning, Heliyon 10: e26218.

[10] Zhang, Y., Huang, Q., Sun, W., Chen, F., Lin, D., Chen, F. (2024) Research on lung sound classification model based on dual-channel CNN-LSTM algorithm, Biomedical Signal Processing and Control 94: 106257.

[11] Erlangga, M.D., Faisal, M.R., Muliadi, M., Indriani, F., Kartini, D., Satou, K. (2025) Incorporating MFCC Feature Extraction to the Classification of Respiratory Sounds by Machine Learning Algorithms. In Proceedings of the 2025 International Conference on Computer Sciences, Engineering, and Technology Innovation (ICoCSETI), IEEE, Jakarta, Indonesia, January 21, 2025, pp. 301-306.

[12] Ruchonnet-Métrailler, I., Siebert, J.N., Hartley, M.-A., Lacroix, L. (2024) Automated interpretation of lung sounds by deep learning in children with asthma: scoping review and strengths, weaknesses, opportunities, and threats analysis, Journal of Medical Internet Research 26: e53662.

[13] Fraiwan, M., Fraiwan, L., Khassawneh, B., Ibnian, A. (2021) A dataset of lung sounds recorded from the chest wall using an electronic stethoscope, Data in Brief 35: 106913.

[14] Bacanin, N., Jovanovic, L., Stoean, R., Stoean, C., Zivkovic, M., Antonijevic, M., Dobrojevic, M. (2024) Respiratory condition detection using audio analysis and convolutional neural networks optimized by modified metaheuristics, Axioms 13: 335.

[15] Suma, K., Koppad, D., Kumar, P., Kantikar, N.A., Ramesh, S. (2024) Multi-task learning for lung sound and lung disease classification, SN Computer Science 6: 51.

[16] Fava, A., Dianat, B., Bertacchini, A., Manfredi, A., Sebastiani, M., Modena, M., Pancaldi, F. (2024) Pre-processing techniques to enhance the classification of lung sounds based on deep learning, Biomedical Signal Processing and Control 92: 106009.

[17] Kim, J.-W., Toikkanen, M., Choi, Y., Moon, S.-E., Jung, H.-Y. (2024) Bts: Bridging text and sound modalities for metadata-aided respiratory sound classification. In Proceedings of the 25th Annual Conference of the International Speech Communication Association (INTERSPEECH 2024), International Speech Communication Association (ISCA), Kos Island, Greece, 1–5 September 2024, pp. 690–1694.

[18] Kim, J.-W., Toikkanen, M., Jalali, A., Kim, M., Han, H.-J., Kim, H., Shin, W., Jung, H.-Y., Kim, K. (2025) Adaptive metadata-guided supervised contrastive learning for domain adaptation on respiratory sound classification, IEEE Journal of Biomedical and Health Informatics 29: 5381-5393.

[19] Chen, J., Guo, Z., Xu, X., Jeon, G., Camacho, D. (2024) Artificial intelligence for heart sound classification: A review, Expert Systems 41: e13535.

[20] Wang, Y., Wahab, M., Hong, T., Molinari, K., Gauvreau, G.M., Cusack, R.P., Gao, Z., Satia, I., Fang, Q. (2024) Automated Cough Analysis with Convolutional Recurrent Neural Network, Bioengineering 11: 1105.

[21] Page, M.J., McKenzie, J.E., Bossuyt, P.M., Boutron, I., Hoffmann, T.C., Mulrow, C.D., Shamseer, L., Tetzlaff, J.M., Akl, E.A., Brennan, S.E. (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews, BMJ 372: n71.

[22] Collins, G.S., Moons, K.G., Dhiman, P., Riley, R.D., Beam, A.L., Van Calster, B., Ghassemi, M., Liu, X., Reitsma, J.B., Van Smeden, M. (2024) TRIPOD+ AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods, BMJ 385: e078378.

[23] Taloba, A.I., Matoog, R. (2025) Detecting respiratory diseases using machine learning-based pattern recognition on spirometry data, Alexandria Engineering Journal 113: 44-59.

[24] Dianat, B., La Torraca, P., Manfredi, A., Cassone, G., Vacchi, C., Sebastiani, M., Pancaldi, F. (2023) Classification of pulmonary sounds through deep learning for the diagnosis of interstitial lung diseases secondary to connective tissue diseases, Computers in Biology and Medicine 160: 106928.

[25] Gupta, R., Singh, R., Travieso-González, C.M., Burget, R., Dutta, M.K. (2024) DeepRespNet: A deep neural network for classification of respiratory sounds, Biomedical Signal Processing and Control 93: 106191.

[26] Truong, T., Lenga, M., Serrurier, A., Mohammadi, S. (2024) Fused audio instance and representation for respiratory disease detection, Sensors 24: 6176.

[27] Moons, K.G., Damen, J.A., Kaul, T., Hooft, L., Navarro, C.A., Dhiman, P., Beam, A.L., Van Calster, B., Celi, L.A., Denaxas, S. (2025) PROBAST+ AI: an updated quality, risk of bias, and applicability assessment tool for prediction models using regression or artificial intelligence methods, BMJ 388: e082505.

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Published

29-06-2026

How to Cite

Deep Learning for Respiratory Sound Analysis: A Systematic Review and Meta-Analysis (2019–2024) (S. M. N. Al-Jabali, F. Nashwan, & W. M. Altalabi, Trans.). (2026). Thamar University Journal of Natural & Applied Sciences, 11(1), 21-28. https://doi.org/10.59167/g1qw6p23

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